Background: Many studies have demonstrated that the geometry of the carotid\nbifurcation enables prediction of blood flow variation associated with atherosclerotic\nplaque formation. The phase angle between the arterial wall circumferential strain and\nits instantaneous wall shear stress is known as stress phase angle (SPA). This parameter\nis used to evaluate hemodynamic factors of atherogenesis. Note that SPA can be\nnumerically computed for the purpose of locating atherosclerosis in different artery\ngeometries. However, there is no experimental data to verify its role in the location of\natherosclerosis in different artery geometries. In this study, we use an ultrasonic biomechanical\nmethod to experimentally evaluate the role of SPA for locating atherosclerosis\nin carotid bifurcation.\nResults: For carotid anthropomorphic vascular phantom experiments, the SPAs\nof common carotid arteries (CCAs), external carotid arteries (ECAs) and internal\ncarotid arteries (ICAs) are âË?â?? 148.53 Ã?± 6.92Ã?°, âË?â?? 153.95 Ã?± 5.11Ã?°, and âË?â?? 238.69 Ã?± 1.72Ã?°,\nrespectively. The corresponding SPAs are âË?â?? 173.47 Ã?± 0.065Ã?°, âË?â?? 115.57 Ã?± 4.83Ã?° and\nâË?â?? 233.9 Ã?± 8.12Ã?° for the polyvinyl alcohol (PVA-c) phantoms. In vivo mouse experiments\nindicated that the wall shear stress and circumferential strain were out of phase in the\nICAs (âË?â?? 280.08 Ã?± 13.12Ã?°) to a greater extent as compared to CCAs (âË?â?? 141.97 Ã?± 8.03Ã?°)\nand ECAs (âË?â?? 170.07 Ã?± 9.24Ã?°).\nConclusions: The results suggested that SPA may be a useful indicator to locate the\natherosclerosis position in carotid bifurcation.
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